Are there any macro buttons in The 4th Coming?

Yes. You can macro most F keys (Except for F1 which opens the Help window). You can also macro all ctrl-F keys. Most ctrl-letters work, but some are already in use to get to the statistic pages.

Most of the macro keys can be set as either ctrl+key or ctrl+shift+key. For example, you can have a potion of lesser healing set as your F2 Macro, and then a Potion of Mana as your CTRL+F2, and then the Light Spell as Ctrl+Shift+F2